We spoke to Gary Sulioti MD, @LindaGr4510 @TimAmrheinMD of @DukeRadiology & @DrIanCarroll about #CSFleak, #intracranialhypotension, & #IIH
Interview ➡️ https://youtu.be/7E5Wi2ST_dc
Manuscript ➡️ https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.14264
Editorial ➡️ https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.14262
Study found that early-onset dementia with Lewy bodies was often misdiagnosed as Alzheimer disease, while #Alzheimerdisease co-pathology was more common in later-onset DLB. https://ja.ma/3GcqoAv
Clinical Reviews Podcast: JAMA Associate Editor @EthanBasch1 and @drmelcalvert of @unibirmingham discuss barriers to and strategies for including rigorous patient-reported outcomes in clinical trials and related ethical implications. https://ja.ma/3FQNzAh
LIFE ITSELF is just 1 week away - final preparations are keeping us busy, so we could learn a thing or two from @goldiehawn. She’ll be speaking about happiness & the importance of quieting your mind. See all 50+ inspiring speakers at http://www.LifeItself.Health
Study found that axonal pTDP43 accumulation in intramuscular nerve bundles might be characteristic for patients with amyotrophic lateral sclerosis. https://ja.ma/3GeftXa
A randomized trial found that limiting recreational screen media use in families substantially increased children’s physical activity. https://ja.ma/3sTxWml
This cross-sectional study found that operating overnight does not appear to be associated with worse outcomes when the attending surgeon continues to operate the next day. https://ja.ma/3yXvcYO
A new study by @theNCI comprehensively described U.S. trends in cancer mortality by cancer site, age, and sex among Black individuals in the U.S. https://ja.ma/3FYrBeE @NCIEpiTraining @BlackinCancer #CancerDisparities
Study found implementation of the acuity circles policy was associated with significantly increased donor delays. https://ja.ma/3NlXj7X
This cohort study found that for some patients, long-term control of #psoriasis and #psoriaticarthritis may require several courses of different agents. https://ja.ma/3NpShqX
Ulcerated plaques on the scalp and dorsal hands of an older man. What is the diagnosis and what would you do next? https://ja.ma/3PrwtNB
Danish cohort study found that people with #bipolardisorder have a higher incidence of osteoporosis than the general population and that treatment with #lithium, but not other mood-stabilizing agents, may reduce this risk. https://ja.ma/3MUvXWt @kohler_ole
A new bill, the Dietary Supplement Listing Act of 2022, would create the impression of reform inthe supplement industry while leaving the current lax regulatory framework largely untouched. https://nej.md/3PrvNIb
FDA updates dates for advisory committee meetings to review pediatric #covid19 vaccines:
June 14: Moderna 6-17yrs
June 15: Moderna 6mo-5yrs, Pfizer 6mo-4yrs
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-announces-tentative-advisory-committee-meeting-schedule-regarding
FDA announces tentative schedule for vaccine advisory meetings, should they have completed applications:
June 7: Novavax
June 8, 21, 22: Moderna & Pfizer/BioNTech in younger populations
June 28: Discussion of strain selection for fall https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-announces-tentative-advisory-committee-meeting-schedule-regarding
The extension of #caplacizumab application intervals from daily to alternate-day dosing may be safely considered after three to four weeks in select patients with #iTTP and offers cost-saving benefits and more individualized therapy https://loom.ly/VkuBUEs
This case report describes a patient in Sweden who had an out-of-hospital cardiac arrest and received defibrillation with an automated external defibrillator delivered by a drone (shown in a video). https://nej.md/3sDQhni
A recent study of mouse models implicates dopaminergic nerve terminals in the amygdala in releasing the brakes on REM sleep and on cataplexy in a mouse model of narcolepsy. https://nej.md/3wj4nwB
This #InternationalDaytoEndObstetricFistula:
Join @FIGOHQ to help women living with obstetric fistula, a devastating childbirth injury, and a neglected public health & human rights issue, to recover & rebuild their lives.
FIGO Fistula Surgery Training Initiative (2022)
Obstetric fistula is a devastating childbirth injury, and a neglected public health and human rights issue, affecting ...
ow.ly
A 61-year-old man presented with a 2-day history of left upper back pain. CT angiography revealed aneurysmal dilatation of the ascending aorta, aortic arch, and descending thoracic aorta. https://nej.md/3lyI1Bb
The FDA recently issued new draft guidance for industry about improving the enrollment of clinical trial participants from underrepresented racial and ethnic populations. Many are part of medically underserved communities. https://ja.ma/3Lu3Hcc
Moderna said in April it is designing a study to evaluate a booster for kids 6 months to under 6 years, but hadn't started the study yet - that may be a bit of a way off
Will be very interesting to see what happens with these two vaccines. The probability that efficacy will improve with a Moderna third dose is obviously very high. https://twitter.com/megtirrell/status/1528692652446781441
One note on differences between Pfizer & Moderna young kids vaccines: Moderna's 2 doses are given 4 wks apart, while Pfizer's 3 are given 3 wks, then 2 months apart. So getting fully vaccinated with Pfizer would take almost 2 months longer. (We will have to see final schedule)
A comparison of what we know about Pfizer & Moderna young kids vaccines as of now:
Age: Pfizer 6mo-under 5 years; Moderna 6mo-under 6
Dose: Pfizer 3 x 3mcg; Moderna 2 x 25mcg
Efficacy: Pfizer 80% (prelim); Moderna 37-51%
FDA status: Pfizer filing this wk; Moderna under review
Pfizer/BioNTech say 3 doses of their vaccine for kids 6 months-5 years met goals of trial & they plan to submit to FDA this week.
Preliminary efficacy against symptomatic #covid19 during omicron: 80%
BREAKING: Pfizer says its COVID vaccine for kids under 5 has met the goals of its clinical trial in terms of the immune response and safety, and plans to file three dose vaccine with the FDA this week.
@megtirrell reports:
Only 1 woman in 50 with an obstetric fistula has access to life-transforming fistula surgery.
On this #IDEOF2022, we support @FIGOHQ's call to close the global treatment gap and end the suffering caused by obstetric fistula. #EndFistula
Join us: http://figo.org/ideof
A 40-year-old man presented to the dermatology clinic with a 2-week history of a scaly foot rash, joint swelling, and low back pain. What is the diagnosis? https://nej.md/2Ku5WxD
ICYMI, Arizona governor OK's ban on school COVID-19 vaccines | AP News https://apnews.com/article/covid-health-doug-ducey-arizona-government-and-politics-777dc3f7c91a191dd33c306579bcace3
#TOPCITED Article
Pre-eclampsia (PE) is a multisystem disorder that typically affects 2–5% of pregnant women and is one of the leading causes of maternal and perinatal morbidity and mortality, especially when the condition is of early onset.
http://ow.ly/QRl950Jeqef
Open Access:
Long-term efficacy & safety of #erenumab in patients with #chronicmigraine in whom prior preventive treatments had failed: A subgroup analysis
@MessoudAshina @StewartTepper @weatherallmw et al
https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.14313
Open Access:
#Migraine & balance impairment: Influence of subdiagnosis, #otoneurological function, falls, & #psychosocial factors
Gabriela Carvalho PT PhD et al
https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.14309
The impact of pre-morbid #headaches on #headache features & long-term health outcomes following #TraumaticBrainInjury: Insights from #ARMR
Z Leibovit-Reiben, @ryotaro_ishii @daviddodick G Dumkrieger, @MCortez_DO @brennan_kc @kathleen_digre @schwedtt
https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.14311
Open Access:
#Triptans & #vascular comorbidity in persons over 50: Findings from a nationwide insurance database – A cohort study
Karin Zebenholzer MD, Walter Gall PhD, Andreas Gleiss PhD, Antun Pavelic MD, Christian Wöber MD
https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.14304
The duration of protection from the BNT162b2 Covid-19 vaccine among children and adolescents is uncertain, particularly amid circulation of the omicron variant. New research findings are summarized in a short video. https://nej.md/3wfvhoZ
Richard Pierson III, M.D., discusses the implications of recent efforts to transplant pig organs into humans. https://nej.md/38qn60c
This article puts climate change in the context of women's reproductive health as a public health issue, a social justice issue, a human rights issue, an economic issue, a political issue, and a gender issue that needs our attention now: http://ow.ly/aJ5V50HT0QO
CDC’s Brian King named director of FDA’s Center for Tobacco Products.
After a robust executive search, I have selected Dr. Brian A. King as FDA’s new Center for Tobacco Products Director. Dr. King brings extensive and impressive expertise in tobacco prevention and control and has broad familiarity with FDA from his more than 10-year tenure at CDC.
Study found implementing the USPSTF 2021 and @AmDiabetesAssn 2022 guidelines would increase screening eligibility among US adults by approximately 6 to 7 percentage points. https://ja.ma/3Lgt80A
Study found addressing the items in the patient-reported outcomes (PRO) ethics guidelines has potential to improve quality of PRO in clinical research while promoting and protecting participant autonomy and protecting participant and researcher welfare. https://ja.ma/3MpDzjE
We know how to define a healthy heart, but how do you really define a healthy brain? @naegelicosta shares her thoughts as well as how to give your brain some love!
🎧 to our full conversation here: https://cnn.it/3LjBgNK
Study found that more all-cause excess mortality occurred in Massachusetts during the first 8 weeks of the #Omicron period than during the entire 23-week #Delta period. #COVID19 https://ja.ma/3lxc0t7
Randomized, phase IIb GeparX study shows denosumab added to anthracycline/taxane-based neoadjuvant chemotherapy does not improve pCR rates. Nab-paclitaxel weekly significantly (α=0.10) increases pCR rates compared to d1,8 q3w, especially in TNBC. https://ja.ma/3lsLwsy #BCSM
Are potential differences in timeliness to surgical care after severe #trauma associated with disparities in discharge outcomes by sex? https://ja.ma/3MtOgC3 @AnneMStey @Martha_IngramMD@NU_SOQIC
In this cohort study, machine learning techniques revealed the substantial clinical and biological heterogeneity in early psychotic and affective illness. These findings may help identify targets for prevention. https://ja.ma/3lk78Y8
In this quality improvement study, primary care–based melanoma screening was associated with increased detection of thin melanoma, raising concern about overdiagnosis. Further studies with longer follow-up are needed. https://ja.ma/3Pvsn76
Study found that at current expected prices, neither aducanumab nor donanemab would be cost-effective for treating early #Alzheimerdisease in the US. https://ja.ma/3kRDXvp
Cross-sectional study found Australia's age-based screen time guidelines don't account for parenting multiple children. #ScreenTimeguidelines/resources should accommodate multi-child families. https://ja.ma/3kx0Q77 @ALSWH_Official
This cross-sectional study identified a small but essential national workforce of clinicians who provide abortions. 88% were physicians, and 12% were advanced practice clinicians like nurses, midwives and physician assistants. https://ja.ma/3y8k7Uw
Following widespread falsehoods about Covid-19 and its treatment and prevention, the ABIM has informed doctors that disseminating misinformation is grounds for disciplinary sanctions. https://nej.md/3liu9uG
The anti-CD19 #CART therapy #tisagenlecleucel was found to be effective and had an acceptable safety profile in patients with refractory primary CNS #lymphoma https://loom.ly/5aj5JP4
The recommendations were developed as a synthesis and update of evidence from the literature. They are based on the @FIGOHQ Safe Motherhood and Newborn Health Committee (SMNH) guidelines published in 2012 and include research and consensus guidelines.
http://ow.ly/Z1a650Je1Lc
