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Intravenous loop diuretics are recommended for fluid overload in acute decompensated heart failure. A new study examined whether adding acetazolamide could improve decongestion. New research findings are summarized in a short video. https://nej.md/3BE8y7y
#CaseReport: a patient was admitted to the hospital owing to sudden-onset involuntary and irregular movements of his left limbs. https://ja.ma/3SNfGGh
Patients were at a x1.56-x4.30 greater risk of experiencing an #opioid #overdose and had $86.37-$366.06 higher health care expenditures in buprenorphine treatment gap months relative to treated months. https://ja.ma/3fyet6H #Research
Understanding patients’ beliefs about treatment success when making decisions about treatment for #appendicitis may be important. https://ja.ma/3SEJbtE #Research
In this non-randomized clinical trial, apremilast may be a safe and efficacious add-on treatment in recalcitrant dermatomyositis with an overall response rate of 87.5%, and functions through downregulation of multiple inflammatory pathways. https://ja.ma/3RxlK48 #Research
Among PMRs and PMCs issued to new FDA-approved drugs between 2013 and 2016, approximately three-quarters of those due by 2020 were not submitted on time. https://ja.ma/3SzuWq3 #Research
White House senior policy advisor for Global COVID Response, @BhadeliaMD, recently spoke with JAMA’s @jenabbasi about the pandemic’s true burden of disease in low- and middle-income countries. #MedicalNews https://ja.ma/3e9MA4I
The October issue is out now! Click below to check out our feature story on the overturn of #RoeVWade and its impact on #hematologic care, a discussion on treatment of #EssentialThrombocythemia, and coverage of the latest clinical news and studies https://loom.ly/wleWs-A
#Viewpoint from Richard O. Hynes, PhD, Erkki Ruoslahti, MD, PhD, and @timothyspringer discusses the rapid advances in molecular cell biological approaches over the past 50 years and the many avenues for future advances that have been opened. https://ja.ma/3EguuIN
@SarahEKline @PCollins_gmh @UnitedGMH
"Given the bidirectional association between HIV and tuberculosis and mental ill health...any strategy to eliminate HIV and tuberculosis must address the mental health and psychosocial needs of those who are infected or at risk of infection"
New Comment
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00343-1/fulltext
In this podcast, JAMA Senior Editor Kristin Walter, MD, MS, discusses the clinical presentation, diagnostic strategies, and treatment of pulmonary embolismwith Yonathan Freund, MD, PhD, professor of emergency medicine at Sorbonne University in Paris https://ja.ma/3C6CnOu
Pediatric thyroid cancer is on the rise. Its genomic landscape is unique; but, this retrospective case series shows that it may still be amenable to molecular classification—potentially decreasing diagnostic surgery & opening avenues for targeted therapy. https://ja.ma/3xtxu0q
Postacute sequelae of SARS-CoV-2 infection (PASC) appears to be uncommon in children and presents with features different from Long COVID in adults, according to a study in JAMA Pediatrics that included almost 700 000 children. #MedicalNews https://ja.ma/3V1yK4N
"It is essential that all health-care professionals and other individuals offering first-line responses and sustaining care have trauma-focused awareness of the potential mental health sequelae of sexual violence."
Linked Comment
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00311-X/fulltext
"Our study highlights the large effect that experiences of sexual violence in adolescence can have on mental health, especially for girls"
New FREE research Article @pravpatalay @F_Bentivegna
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00271-1/fulltext
Single-arm, phase 2, 2-stage, non-randomized clin trial of avelumab + talazoparib combination in 35 pts w/recurrent mismatch repair proficient endometrial cancer showed ORR 11.4% & PFS at 6 mo 22.9%, w/favorable side effect profile. https://ja.ma/3Bl3uom
Health care practitioners should be aware of out-of-pocket expenses and the association of the location where gender-affirming surgery is performed with patients’ costs when possible. https://ja.ma/3LcK9KC #Research
#CaseReport: a woman in her 50s with obesity, end-stage kidney disease, and type 2 diabetes who presented with severe painful, erythematous nonhealing ulcerated skin lesions with necrotic eschars on the right lower abdomen. https://ja.ma/3fasSFV
Review discusses the incidence, diagnosis, symptomatic characteristics, treatment, and prognosis for patients with #PulmonaryEmbolism. https://ja.ma/3SSNeCj
Gabapentin was a cause of death in thousands of US overdoses last year. Growing evidence of misuse and fatal overdoses involving #gabapentin—often in conjunction with opioids—is drawing attention to off-label prescribing, @bmkuehn reports. https://ja.ma/3fEdIZW #MedicalNews
In this national cohort study of over 4,000 individuals undergoing gender affirming-surgery, #mentalhealth conditions were associated with increased odds of postoperative complications. https://ja.ma/3SC9m4l @AdanZBecerra1 @RushSurgery
Listen to a summary of the October 4 issue of JAMA by Associate Editor Linda Brubaker, MD, MS. @AMAEDHub #podcast https://ja.ma/3Cak36P
A patient in their 40s with no previous medical history who presented to the emergency department with acute chest pain. https://ja.ma/3E975Jr #CaseReport
This study contrasting case-control and normative modeling approaches found that brain volume deviations are better predictors of subsequent antipsychotic treatment response in medication-naïve first episode psychosis patients than raw volume measures. https://ja.ma/3UQsgFR
In pts w complicated UTI or acute pyelonephritis caused by gram-negative pathogens, cefepime/enmetazobactam, vs piperacillin/tazobactam, met criteria for noninferiority & superiority w respect to primary outcome of clin cure & microbiological eradication https://ja.ma/3e9bq4v
A self-care intervention is feasible and potentially comparable to a comprehensive, therapist-guided version,2 provided that the intervention is well designed and includes clinical interviews and on-demand technical support. https://ja.ma/3xYSOLe #Research
A conflicting case of #ophthalmoparesis. Take the #ClinicalChallenge. What is your diagnosis? https://ja.ma/3Sw6dTj
To address the mortality and morbidity associated with the current #MentalHealth (MH) crisis, subspecialty fellows in all disciplines may benefit from curriculum reform with increased focus on MH skills. https://ja.ma/3fCzoWp #Research
First, explain why your request is appropriate and justified. Second, share why your proposal serves the interest of both parties
#1: Men negotiate, and women don’t. https://hbr.org/2022/10/3-negotiation-myths-still-harming-womens-careers?utm_campaign=hbr&utm_medium=social&utm_source=twitter
1 week left to register to vote in OHIO #voteready 🗳🇺🇸🩺
The Registration Deadline for the November 8, 2022 General Election is October 11th. That's 1 week away!!!
Register to vote or update your registration today at http://www.VoteOHio.gov
A #PulmonaryEmbolism (PE) is a blood clot that blocks a blood vessel in the lung. This JAMA Patient Page discusses the diagnosis, treatment, and potential consequences of PE. https://ja.ma/3C7PU8v
Study found differences in rates of amyloid positron emission tomography positivity among racial and ethnic groups. https://ja.ma/3RxrI4T #Research
In this ecological study, melanoma incidence was weakly correlated with proxies of UV exposure and more strongly related to proxies for diagnostic scrutiny. Melanoma incidence in the US is less the result of UV and more the result of diagnostic scrutiny. https://ja.ma/3Rxruuz
This case report describes dry skin with marked redness of the face and hands as well as trichorrhexis invaginata. https://ja.ma/3ryr2C1 #Research
Exploring mechanisms underlying genome-by-trauma exposure interactions may be useful in identifying at-risk individuals and intervention targets in #depression. https://ja.ma/3SEkNb1
Early steroid administration was not associated with hospital length of stay in a study of 1163 children hospitalized with non-MIS-C #COVID19 and entered in the SCCM VIRUS:COVID 19 registry. https://ja.ma/3UXhCNL #Research
Same-day discharge after minimally invasive #colectomy is the next generation of enhanced recovery pathways for colorectal surgery. https://ja.ma/3xZhN14
It’s a great today to make sure you’re #voteready 🗳🩺🇺🇸 https://twitter.com/RockTheVote/status/1577308833919254532
#Breastfeeding is at the core of the 2030 #SDGs and @WHO best practice recommendations suggest it can have profound benefits for both mother and baby.
Read @FIGOHQ’s latest statement about the first golden hour of life: http://ow.ly/XJJZ50KaQ1W
#COVID Vaccine Spoilage: Data from the #CDC revealed 82.1 million #vaccine doses were discarded between December 2020 and May 2022 after expiring or spoiling. Wasted doses have been attributed to a lower public demand for boosters, as well as large minimum order requirements.
An investigation by CDC and state health authorities in Utah found #monkeypox virus on many frequently used household surfaces, blankets, furniture, and other objects in a home where residents had been isolating for weeks. https://ja.ma/3fgJAn8 #MedicalNews
Quality imprvmnt study of 304 trials submitted for @US_FDA registration of 115 anticancer meds over 10 yrs shows 137 (45%) eligible for sharing of individual pt. data: substantial proportion of trials for FDA registration remain unavailable to researchers https://ja.ma/3QMkj1n
A trial that evaluated 3 existing generic medications—metformin, ivermectin, and fluvoxamine—for early outpatient treatment of #SARSCoV2 infection among adults with overweight and obesity did not prevent progression to severe #COVID19. https://ja.ma/3rfUGM3 #MedicalNews
Uterus transplant may be a viable method for women with uterine-factor infertility to have children. https://ja.ma/3UcG0L1 #Research
Postpartum social problems, such as postpartum depression (PPD) and bonding disorders, are important risk factors for child maltreatment, a global social issue that needs to be addressed.
Read the full article here: http://ow.ly/eMvL50KW7fW
Multicenter cohort study of 802 pts w/nasopharyngeal carcinoma (NPC) shows existence of microbiota within NPC tissues, & intratumoral bacterial load was assoc'd w/poor survival & negatively associated with T-lymphocytle infiltration. https://ja.ma/3Ufx87a
Viewpoint explains how a recent Supreme Court decision clarifies rules for prescribing controlled substances so that patients are not denied appropriate care and physicians are not unjustly prosecuted. https://ja.ma/3SBilmi
Work relative value units and, consequently, compensation may be lower for pediatric dermatologists because pediatric encounters are more likely to include medical management and clinical counseling rather than procedures. https://ja.ma/3SJ6iTh #Research
Listen to a summary of the October 3 issue of JAMA Pediatrics by Editor in Chief Dimitri A. Christakis, MD, MPH, and Associate Editor Alison A. Galbraith, MD, MPH. https://ja.ma/3UYnyWH @AMAEdhub #Podcast