"...for clinicians, it can be difficult to distinguish adolescents who will eventually develop persistent depression with poor adult outcomes from those whose depression will spontaneously remit"
@wolfsoncentre
New Research
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(21)00281-9/fulltext
The resolution calls on the NYC’s Department of Health and Mental Hygiene to take steps including reviewing the city’s health code to look for structural racism, and find ways to make changes as necessary. https://apnews.com/article/health-wisconsin-new-york-new-york-city-public-health-d702a7e81ac4c35e7f5d3ab532d7fe66
I mean I guess it wouldn’t be a true Boston event without some beatboxing? #HLTH21
In an analysis of the phase III RATIFY trial published in @LeukemiaJnl, researchers examined the molecular landscape of FLT3 internal tandem duplication mutations in acute myeloid #leukemia (#AML) https://www.ashclinicalnews.org/news/literature-scan/study-explores-molecular-landscape-prognostic-impact-flt3-itd-insertion-site-patients-aml/
Congratulations to NEJM Editor-in-Chief Eric J. Rubin, M.D., Ph.D., who was elected today to @theNAMedicine for pioneering bacterial genetic tools being used to create the next generation of anti-tuberculosis drugs. #NAMmtg https://nej.md/30EkzLx
In this editorial, Daniel H. Geschwind, M.D., Ph.D., reviews Sikich et al.'s trial of oxytocin as a treatment in children and adolescents with autism spectrum disorder. https://nej.md/3v7cTfT
A new meta-analysis shows that behavioral interventions are effective in treating social deficits in children and adolescents regardless of neurodevelopmental or #mentalhealth diagnosis https://ja.ma/3lPT7Cw
Cohort study found plasma GFAP is an earlier and more specific biomarker of amyloid-β pathology than CSF GFAP in #Alzheimerdisease https://ja.ma/3ANtoPj @goteborgsuni @fpmaragall @CNC_Alzheimer @Imaging_AD @AD_McGill
Estimated utilization of new oral targeted cancer drugs without documented overall survival benefit among Americans with employer-sponsored insurance has substantially increased over the past decade, with major cost implications https://ja.ma/3aP3dxi
A genome-wide association study identified a new genetic locus within the NEDD4L gene to be associated with acute appendicitis. NEDD4L was also among the top differentially-expressed appendiceal genes between appendicitis patients and controls https://ja.ma/3vb4OqD
In patients with #cirrhosis who have portal vein #thrombosis (PVT) and undergo liver transplant, therapeutic anticoagulation was associated with significantly higher rates of bleeding and did not prevent post-transplant PVT recurrence https://www.ashclinicalnews.org/news/literature-scan/therapeutic-anticoagulation-not-prevent-pvt-recurrence-liver-transplant/
Disruptions in neural and behavioral measures of reinforcement learning characterize symptoms of depression; remediation of these learning disruptions was associated with symptom improvement after #cognitivebehavioraltherapy https://ja.ma/2YrtQ8k
Phase 3 Lung-MAP S1400I trial of nivolumab with or without ipilimumab in chemo-pretreated advanced NSCLC demonstrates no significant efficacy benefit from combination over nivo alone https://ja.ma/3AhFYqN #LCSM
There is a need for improved production of the influenza vaccine. In a trial involving healthy children, a cell-culture–derived quadrivalent influenza vaccine had efficacy against the circulating influenza serotypes. https://nej.md/3v8t4JL
Safe, affordable housing is a foundation of good health. Safe, affordable housing is a foundation of good health. The #COVID19 pandemic both highlighted eviction as a public health crisis and exacerbated the problem. https://nej.md/2YSNydZ
To revise the FIGO staging for carcinoma of the vulva using a new approach that involves analyses of prospectively collected data. FIGO reviewed the recent literature to gain an insight into the impact of the 2009 vulvar cancer staging revision: http://ow.ly/xVFl50GrVFZ
An immunocompromised patient presented to the ED with confusion. He later became obtunded, and an MRI of the head revealed ring-enhancing lesions. https://nej.md/3FMEd8i
MRD was not associated with improved progression-free survival in patients with chronic lymphocytic #leukemia (#CLL) who were on indefinite ibrutinib-based therapy or who received 6 cycles of fludarabine, cyclophosphamide, and rituximab https://www.ashclinicalnews.org/news/from-the-blood-journals/written-in-blood/mrd-predict-pfs-patients-cll-indefinite-ibrutinib-based-therapy/
Congratulations to @rachel_kowalsky, winner of our 2021 NEJM Medical Fiction Contest. Read her story and the stories from runners up @Rhythmqueen94 and @alessacolaMD now. https://nej.md/3BIUHvy
Fetal scalp stimulation is easy to perform and can be useful when reduced variability is the main cardiotocography feature, as the appearance of accelerations and a change to a normal pattern is very predictive of absent hypoxia/acidosis: http://ow.ly/3Ate50GrVRt
NEJM Image Challenge: An 82-year-old man with diabetes presented to the ED with fever and confusion. Liver function test showed aspartate aminotransferase level of 1380 u/l. What is the most likely diagnosis? https://nej.md/2Ku5WxD
At least two dozen lawsuits have been filed around the U.S. by people seeking to force hospitals to give their COVID-stricken loved ones ivermectin, a drug for parasites, despite a lack of conclusive evidence it helps people with the virus.
Lawsuits demand unproven ivermectin for COVID patients
NEW YORK (AP) — Mask rules, vaccination mandates and business shutdowns have all landed in the courts during the...
apnews.com
The intergenerational impact of poor maternal nutrition and health conditions during pregnancy, particularly NCD-related pregnancy complications, can be considered as a multiplier of the ongoing pandemic of NCDs: http://ow.ly/elwS50GrVCD
R. Alta Charo, J.D., discusses a law that allows members of the public to file suit against abortions in Texas. https://nej.md/3DzqorN
Sodium–glucose cotransporter 2 inhibitors have been shown to improve outcomes in patients with heart failure, but whether they improve outcomes in patients with a preserved ejection fraction is uncertain. https://nej.md/3axSR4y
States can reserve COVID-19 shots for younger kids next week https://apnews.com/article/coronavirus-pandemic-science-health-coronavirus-vaccine-centers-for-disease-control-and-prevention-84ff9189e142536f90940366bcfa3f22
CDC advisory meeting draft agenda posted for next week! Thursday is the day for #covid19 boosters: https://www.cdc.gov/vaccines/acip/meetings/downloads/agenda-archive/agenda-2021-10-20-21-508.pdf
And now CDC sets advisory meetings for boosters & kids #covid19 vaccines:
Oct 20-21 to discuss Moderna, J&J boosters
Nov 2-3 to discuss pediatric #covid19 vaccination
https://www.cdc.gov/vaccines/acip/index.html
(h/t @erikaedwardsnbc) https://twitter.com/megtirrell/status/1444006310530453505
A panel of U.S. health advisers endorsed booster doses of Johnson & Johnson’s single-shot COVID-19 vaccine Friday, saying they should be offered at least two months after immunization. https://apnews.com/article/coronavirus-pandemic-science-business-health-coronavirus-vaccine-53aaa9bfe4d05656aa52e251ba2b5401
FDA advisers vote on J&J:
Do data support J&J boost for all 18+ at least 2 months after single dose?
Yes: 19
No: 0
Abstain: 0
The Mexican government’s point man for the coronavirus pandemic has once again made waves by calling those who wear facemasks “egotistical people.” Social media users expressed outrage at the comments by Assistant Health Secretary Hugo López-Gatell. https://apnews.com/article/coronavirus-pandemic-entertainment-lifestyle-media-mexico-city-e74748b40a85ed2c0b12c7e5fe81d865
Chicago Mayor Lori Lightfoot said Friday that she took her fight with the head of the city’s police officers union to court, arguing that his call for officers to ignore the order to report their COVID-19 vaccination status was illegal. https://apnews.com/article/coronavirus-pandemic-health-police-chicago-lori-lightfoot-2f7c08e8a5942f24b273bca872766a5b
Pfizer and BioNTech said Friday they have requested to have their coronavirus vaccine licensed for children ages 5 to 11 across the European Union. https://apnews.com/article/coronavirus-pandemic-business-health-europe-coronavirus-vaccine-93bbf6bac1f54036d0d50092d54a852f
IJGO is delighted to share a new special issue which is a call for action from everyone who works in women's health, and a call to listen to the voices of Indigenous women, researchers, and clinicians: http://ow.ly/qtyS50Gsdax
Congratulations to @rachel_kowalsky for her winning entry in the 2021 NEJM Medical Fiction Contest. Read her story "The Billboard," only on NEJM. https://nej.md/3DHiLzF
Challenges of pregnancy as a surgeon: Compared to male surgeons & their partners, female surgeons
•More likely to delay children & need assisted reproduction
•Have 1.7X ↑ risk pregnancy complications;long OR hrs ↑risk by 1.6x
•↑ risk postpart https://ja.ma/3vjyull
Pediatric patients with HS may be under diagnosed. Education directed at primary care providers regarding early manifestations and comorbidities may aid in early recognition of HS and facilitate specialist referral for outpatient treatment https://ja.ma/3EnUNdF
In CA, FL, and NY, prices paid to anesthesiologists in hospital outpatient departments and ASCs decreased after the introduction of surprise billing legislation, providing early insights into how prices may change under the federal No Surprises Act https://ja.ma/3D2eKW6
Study suggests that high screen time contributes to adverse cognitive, executive function, and behavior outcomes at ages 6 to 7 years in children born at less than 28 weeks https://ja.ma/3De6u5d
Meta-analysis found impaired cognitive functioning in healthy individuals infected with the highly prevalent parasite Toxoplasma gondii. The impact of these impairments on global #mentalhealth could be substantial https://ja.ma/3Ah818M
Based on a sample of blood donations in the US from July 2020 through May 2021, estimated #SARSCoV2 seroprevalence increased over time and varied by age, race and ethnicity, and geographic region https://ja.ma/3lBrxch
The rand phase 2 trial PREDIX HER2 compared neoadjuvant standard treatment with docetaxel, trastuzumab & pertuzumab with T-DM1, including 197 patients with HER2-positive #BreastCancer. The primary endpoint, pCR rate, was similar in both study groups https://ja.ma/3nJSgVz #BCSM
In this study, different pathological features on head computed tomography carried different implications for mild traumatic brain injury prognosis to 1 year https://ja.ma/2XoMI7B
Props to FDA's A/V technician, whose musings speak for us all.
Waiting for a speaker w technical issues just now, he sang "doo doo doo" 🎶
Then cheered for said speaker - "Alright, Arthur!" when his system finally worked
Cheerful problem-solvers 💪
In 290 participants 3 to 17 years old with autism spectrum disorder, daily use of oxytocin did not improve measures of social interaction as compared with placebo over 24 weeks. https://nej.md/3DzzMM3
The FIGO pragmatic guidelines for hyperglycemia in pregnancy/GDM provide a workable framework for accommodating differing diagnostic and therapeutic approaches to GDM across a variety of countries and healthcare systems: http://ow.ly/P5C350GrVzH
First Q to J&J in FDA advisory mtg on boosters boils down to, if I'm interpreting right: Why isn't this a 2-dose vaccine?
Dr Hayley Gans says: "I'm not seeing the rationale of waiting for boosting if our goal is making this as efficacious" as we can, noting 2 doses hits 90%+ VE
🎧🎙If you missed Ep6 of @WPSA1 podcast w @MargMckenzieMD be sure to give a listen! Great conversation abt #leadership in #healthcare, authenticity & being a #womeninmedicine #sheleadshealthcare #subscribetoday https://my.clevelandclinic.org/podcasts/inspirations-and-insights/margaret-mckenzie-md
A patient with sickle cell trait presented with sore throat and petechiae of the oropharynx. Hemoglobin level was 9.8 g per deciliter and white-cell count 670 per microliter. A test for #SARSCoV2 RNA was positive. https://nej.md/2X8XWxf
