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Thank you @ASlavitt — I am humbled and honored.
Today is 20 years for @drsanjaygupta at @CNN.
Sanjay has been a gift to all of us who care about journalism, humanity, our health, and about getting the facts when things get complex.
Houston's NRG Park, a FEMA #covid19 vaccination site, is now accepting anyone 16+ who arrives for a shot, no appmt needed. We spoke with @LinaHidalgoTX about what they're seeing in terms of vaccine demand & how they're trying to make it easier for people to get vaccinated.
All Americans 16+ are now eligible for a Covid vaccine. But some are still hesitant. @megtirrell reports.
JAMA Insights Clinical Update: review of the evolution in the types of corneal transplants performed over the past 20 years, including the shift from full-thickness replacement of the entire cornea to selective transplant of just the affected layer(s) https://ja.ma/3sxxRBu
Use and overuse of peripheral intravenous catheters: Recommendations from a #teachablemoment to both improve patient care and decrease wasteful hospital spending https://ja.ma/3glFngq
Heather C. Milbar, MD, and Marcus Conant, MD, discuss The Role of Dermatologists in the Early HIV/AIDS Epidemic. Listen to the discussion https://ja.ma/2P5Tb2Y
Some of Alaska's highest vaccination rates have been in some of its remotest, hardest-to-access communities. Story by @beckybohrerap https://apnews.com/article/us-news-alaska-bering-sea-coronavirus-pandemic-d992db954b2cdc264327fb72a6a85375
In the 1960s, Pittsburgh’s Freedom House Ambulance Service supplanted the police in a role in which they were not effective, reimagined the role of Black citizens in improving community health, and helped establish national standards for emergency medical care.
Chronic kidney diseases generally arise from a disordered kidney filtration barrier within glomeruli. This review describes the roles of glomerular capillary pressure, the glomerular basement membrane, and podocytes in regulating glomerular filtration and permeability.
JAMA Patient Page summarizes the #USPSTF 2021 recommendation that current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults (I statement). https://ja.ma/3uGfxrs
In a neonate born at 37 weeks of gestation, the small bowel and colon protruded through a defect in the abdominal wall, a condition referred to as closed gastroschisis.
Today for the 1st time #COVID19 #vaccines are available to all people 16 & older in the US. @WHCOVIDResponse's @ASlavitt says 90% of Americans are within 5 miles of a site. #GetVaccinated- it's a critical tool to stop the pandemic. Where to get yours? https://www.cdc.gov/vaccines/covid-19/reporting/vaccinefinder/about.html
85 dead from methylene chloride, finds first broad review of cases in US. Clinicians and better policy can help prevent fatalities @UCSF_PRHE @OSHA_DOL @UCSFMedicine @NRDC
Assessment of Methylene Chloride–Related Fatalities in the United States, 1980-2018
This case series analyzes characteristics of methylene chloride–related fatalities in the United States from 1980 to 2018.
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Nearly 50% of unselected patients undergoing brain MRI will have at least one MRI sign of intracranial hypertension, but this finding is rarely associated with papilledema https://ja.ma/3eco6DT @vbiouss
A cohort study of 123,175 offspring born in Manitoba, Canada from 2005 to 2016 found that epidural labor analgesia is not associated with an increased risk of autism spectrum disorder in the offspring https://ja.ma/3sqkXp6
Amongst pts w PD-L1>50% #NSCLC treated w ICI, KRASm assoc w ↑ survival c/w KRASwt (mOS 21.1 vs 13.6 mos). KRASwt had numerically worse survival w ICI monotherapy c/w chemoIO (mOS 13.6 vs 19.3 mos), suggesting that chemoIO might be favored despite ↑ PD-L1 https://ja.ma/3ae1FwG
16 years of follow up there was no difference in allograft or patient survival between kidney transplant patients treated with tacrolimus and MMF maintenance immunosuppression who were randomized to continue or withdraw corticosteroids https://ja.ma/3e5N6wi #nosteroids
HCWs at @UMMC w serology-defined prior #COVID19 infection had higher Ab titer responses to single-dose mRNA vaccine vs those not previously infected, informing proposals that the former may be protected w single-dose vaxx or be lower vaccination priority https://ja.ma/3s95OIA
Critically assessing the role of dermatologists in the early #HIV / #AIDS epidemic for the 40th anniversary of the HIV/AIDS epidemic https://ja.ma/3vCwFQn
Israel appears to be out front on #covid19 vaccines once again. Pfizer CEO notes the co just signed its first 2022 govt supply agreement, w Israel.
.@Pfizer & governments around the world are working on longer-term pandemic preparedness. Today we signed our first 2022 government agreement with Israel to supply millions of doses of the Pfizer-BioNTech #COVID19 vaccine with the option to purchase millions of additional doses.
AstraZeneca told us March 22 (https://www.cnbc.com/video/2021/03/22/astrazeneca-trial-data-united-states-approval-plans.html) they planned to file for FDA Emergency Use Authorization of their #covid19 vaccine in the first half of April. No sign of it yet.
“No doubt we will all rejoice when the country’s political fever defervesces and science regains its critical, objective role in society … Until then, let’s support each other in every way we can.” —@jmikhaelmd https://www.ashclinicalnews.org/viewpoints/editors-corner/editors-corner-post-pandemia-mania/
Amnesty International's updated policy can be a useful resource for providers who seek to promote reproductive autonomy and achieve better health outcomes for their patients: http://ow.ly/wtsM50Es68s
Abbott's BinaxNOW self #covid19 test will be available in stores for $23.99 for a 2-pack: https://abbott.mediaroom.com/2021-04-19-Abbott-Begins-Shipping-BinaxNOW-TM-COVID-19-Ag-Self-Test-to-Retailers-Today
How many looked startled by a man jogging through Central Park greeting everyone he passed?
On my run through Central Park this morning, I made a point of saying “Good morning!” to every person I encountered.
I encountered 355 people.
128 said “Hello” or “Good morning” back.
41 gave a head nod
186 didn’t acknowledge
(165 wore headphones, some whom did reply)
In the @NEJM Covid-19 Vaccine Resource Center, @PaulSaxMD provides concise and engaging answers to clinicians’ questions about Covid-19 vaccination and to the questions and concerns patients will raise. #SARSCoV2 #IDTwitter
Note, all doses of J&J #covid19 vaccine used in the U.S. so far were manufactured in the Netherlands; J&J needs FDA authorization of Emergent plant to start supplying from the U.S. (and presumably to meet its goal to supply 100M doses by the end of May)
Emergent BioSolutions, J&J’s US manufacturing partner on #covid19 vaccine, says FDA started inspection April 12, after reported cross-contamination ruined batch of up to 15M doses. FDA asked Emergent to halt manufacturing while it completes investigation https://www.sec.gov/ix?doc=/Archives/edgar/data/1367644/000136764421000066/ebs-20210419.htm
Emergent BioSolutions, J&J’s US manufacturing partner on #covid19 vaccine, says FDA started inspection April 12, after reported cross-contamination ruined batch of up to 15M doses. FDA asked Emergent to halt manufacturing while it completes investigation https://www.sec.gov/ix?doc=/Archives/edgar/data/1367644/000136764421000066/ebs-20210419.htm
Scientists and even business leaders are calling on Biden to target cutting U.S. greenhouse gas emissions by at least 50% below 2005 levels by 2030. Anything short of that could undermine Biden’s promise to halt temps from rising more than 1.5 degrees C. https://apnews.com/article/joe-biden-politics-climate-climate-change-summits-c02ea56b944d01c812644900fce803e7
Pfizer & BioNTech to supply additional 100M doses of #covid19 vaccine to Europe this year
FDA should have led J&J #covid19 vaccine decision-making, former commissioner @ScottGottliebMD writes in @WSJ. “Putting the issue before the CDC confused the process and slowed the decision.” https://www.wsj.com/articles/drug-safety-is-fdas-job-not-cdcs-11618780270?mod=opinion_lead_pos11
#Casereport: 3 patients with focal acantholytic dyskeratosis https://ja.ma/30RCZ8h
Nearly one-quarter of physicians reported being personally attacked on social media https://ja.ma/3cQy5PF
In this RCT of 200 surgical clinic patients, surgeons wearing a clear mask were rated significantly higher for providing understandable explanations, demonstrating empathy, and eliciting trust https://ja.ma/3mKFKT7 @IanKratzkeMD @muneerakapadia @UNCSurgery
How well does the #depression polygenic score in combination parental psychosocial factors determine the absolute risk for depression before age 30? https://ja.ma/3wu4nrw
Study presents worldwide, first-time evidence that motor spinal levels and, consequently, functional mobility are better in school-aged patients with a history of prenatal rather than postnatal SB surgery https://ja.ma/3mm4W1X
Postoperative radiotherapy (PORT) is a treatment option for microscopic residual disease of a cutaneous squamous cell carcinoma if re-excision (the gold standard) is not possible. Current tumor staging does not seem to predict poor outcome after PORT https://ja.ma/3cLVEYV
“You wonder if there are any better creatures than humans.”AP PHOTOS: Photographers reflect on their powerful images of the pandemic (from @AP) https://apnews.com/article/ee22b9c3badb6f8b0343b6b7a5ea49ae
A 27-year-old primigravid woman was admitted with new-onset diabetes and hypertension at 32 weeks of gestation. Physical examination showed striae over the abdomen, breasts, and dorsal and supraclavicular fat pads. What is the most likely diagnosis?
By addressing nutrition and weight with women of reproductive age, outcomes can be improved and the burden on healthcare systems reduced: http://ow.ly/3nYW50Eqafz
The NEJM Clinical Cases Resource Center aggregates interactive cases and educational resources developed specifically for teaching, continuous learning, and professional development.
Such an honor to receive this award @davideagleman — especially coming from you.
Want to donate to brain research? Come to the American Brain Foundation's virtual gala April 21, celebrating those who seek treatments, preventions, & cures for brain disease. I'll present the Public Leadership Award to Dr. Sanjay Gupta. Tickets here: https://www.americanbrainfoundation.org/c2c2021/
Study by @sydney_l_olson et al reports on growth rates and patterns of 254 patients with 3.5-5.0 cm abdominal aortic aneurysms with serial CT imaging. Key findings: average growth=.19 cm/year, 70%=linear growth, staccato and exponential growth infrequent https://ja.ma/3deRHNJ
#Casereport:13-year-old boy presenting with left-sided facial droop and dysarthria with workup revealing distinguishing features leading to diagnosis of #neurosarcoidosis
Cortical Vein Thrombosis, Tortuous Venous Vasculature, and Microhemorrhages in Neurosarcoidosis
This case report describes a 13-year-old boy who presented with an episode of left-sided facial droop and dysarthria lasting 90 minutes.
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Delayed umbilical cord clamping should be the preferred strategy for preterm infants; however, larger trials directly comparing delayed umbilical cord clamping and umbilical cord milking are needed https://ja.ma/3fF0Alj
The proportion of patients with androgenetic alopecia increased from 4 to 31 after masculinizing hormone therapy (MHT) initiation, with the highest incidence in the fourth year of MHT and the median duration of MHT prior to diagnosis 2.8 years
Androgenetic Alopecia Among Transgender and Gender-Diverse Patients Treated With Masculinizing Hormone Therapy
This cohort study examines the proportion of transgender and gender-diverse individuals patients receiving masculinizing h...
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Nonanastomotic biliary strictures are a major complication after liver transplantation, and ischemia–reperfusion injury is a key mechanism in their development. New research findings on methods of preservation to protect from injury are summarized in a short video.
AV dissociation in a #hearttransplant recipient. After a heart transplant surgery, the patient has sinus dysfunction, which requires the implantation of a DDD Pacemaker, the right atrium lead carefully placed in the donor atrium to ensure AV synchrony https://ja.ma/3fJeLpi
Covid-19 Rx: Your task is to gather data, develop a differential diagnosis, order additional diagnostic tests, and treat the patient. (Optimized for desktop PCs and most tablets.) #COVID19