Perspective: Last Song — Sharing Humanity while Maintaining Boundaries https://nej.md/2qQewBy
A patient’s dermatologist should play an important role in optimizing the multidisciplinary management of #Merkelcell #carcinoma https://ja.ma/2KnHrnh https://ja.ma/2OtVSYz
Prices of self-administered MS DMTs quadrupled in 2006-2016, leading to a 7-fold increase in patients' out-of-pocket costs @asjrodriguez @ihdezdelso https://ja.ma/34UQQe9 @jamaforum
Nonalcoholic fatty liver disease (NAFLD) is fatty accumulation and inflammation in liver cells from causes other than alcohol use. Over time, it can progress to nonalcoholic steatohepatitis (NASH), accumulation of fat in the liver that causes scarring https://ja.ma/32GcYHt
Promoting positive childhood experiences buffers risks for adult #mentalhealth and relational health despite multiple adverse childhood experiences https://ja.ma/339EJJs
Intakes of protein from plant origin are associated with lower mortality risk in the Japan Public Health Center-based Prospective Study. https://ja.ma/2WB7FIc
B-Con principles for correct CAT application are NOT fully translatable to OTHER commercial or improvised tourniquets https://ja.ma/2MornmZ @JustinCMcCarty #StopTheBleed
Perspective: Modernizing the FDA’s 510(k) Pathway https://nej.md/34VFmXG
As countries begin to implement counselling interventions, it is important that evaluations of the interventions document women's experiences, perceptions, and feelings about the outcomes, alongside measuring the impact on health outcomes: http://ow.ly/dVri50wOzWJ
#MostDownloaded
This review discusses three ethical challenges in neural devices research: analyzing risk, informed consent, and post-trial responsibilities. #neuroethics https://ja.ma/2OMrES9
Attending #AHA19? Press PLAY on JAMA Network's Cardiology playlist to ease your way from the hotel shuttle to the convention center to each of the Scientific Sessions! https://open.spotify.com/playlist/0UJTZtS5DwK8rAXcIi20kg?si=b8POm0ybRaS_s4KukPP_Bg #NowPlaying
Audio #AHA19 Update
ISCHEMIA Trial: No difference in CV outcomes w optimal medical therapy vs revascularization for stable IHD, w same findings in CKD patients
COLCOT Trial: In patients with recent AMI, colchicine reduced CV events
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Latest Quick Take video: A New Vaccine against Smallpox.
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Analysis of the NSQIP database reveals emergency colectomy for lower GI bleeding is associated with high 30-day mortality https://ja.ma/2CM1yHz @enenbee @colinscl
Time for neurologists to step up and manage HTN to prevent neurologic disease. https://ja.ma/34RLiBa
I found peace in my dad’s passing, because it was what he wanted. But my grieving heart wanted more from him. https://ja.ma/36ZnVHs https://ja.ma/2NZMriY
Find COLCOT, RECOVERY, GALILEO, and GALILEO 4-D, as well as @JWatch summaries, on our #AHA19 page https://www.nejm.org/aha
Visit https://nejm.org/aha for full access to articles for seven days after meeting with free registration.
In GALILEO substudy of patients undergoing 4D CT, leaflet thickening and reduced leaflet motion at 90 days were less common with rivaroxaban, but rivaroxaban associated with a higher risk of death or thromboembolic events. See GALILEO-4D trial. #AHA19 https://nej.md/2ObQysn
Patients who had had successful TAVR randomized to either a rivaroxaban-based antithrombotic regimen or an antiplatelet-based regimen. At 17 mos, death or thromboembolic complications occurred more frequently w/ rivaroxaban. See the GALILEO trial. #AHA19 https://nej.md/2qgRQdE
Editorial on the RECOVERY trial: Timing of Intervention in Aortic Stenosis #AHA19 https://nej.md/2OdeM5E
At a median of 6 years of follow-up, operative mortality or CV death occurred less frequently in asymptomatic patients with very severe aortic stenosis who received early valve replacement surgery than in those conservatively managed. #AHA19 https://nej.md/2Qhrymk
Original Article: Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation https://nej.md/32FaVDv
How to help adolescent boys better understand their needs for intimacy, help them better relate with people, and preempt unpleasant behaviors; an interview with @niobe_way #thelisteningproject #tedmed #loneliness #friendships@pachnyu https://ja.ma/2OmcQHU
The Cutaneous Sarcoidosis Activity and Morphology Instrument was responsive to changes in cutaneous sarcoidosis disease activity over time https://ja.ma/2XgaZsq https://ja.ma/2NP6kup
Identifying how specific screen-based media elements impact on well-being and functioning poses both conceptual and empirical challenges https://ja.ma/2oEWotN
A temporary moratorium on new #opioid approvals is the best path forward for #publichealth https://ja.ma/2WB7Fba @jamaforum
Perspective: Learning from the Dead https://nej.md/2QprTUd
Machine learning applied to develop & train an algorithmic classifier of primary cancer of origin from genomic features shows ability to classify ~75% of tumors, w same results from plasma https://ja.ma/2QkBVWD https://ja.ma/2KnINi6
Meta-analysis of over 40 studies indicates delay discounting-preferences for immediate vs delayed rewards-is a transdiagnostic process in #psychiatry with potential for broad clinical use as a biomarker and treatment target. https://ja.ma/2Kp5D8X https://ja.ma/2KnLEYm
Ultimately, the phenomenon of vaccine misinformation is likely an amalgam of broader issues, such as concerns about vaccine safety and mistrust in the pharmaceutical industry and government agencies https://ja.ma/2JHImyO @jamaforum
#Casereport: electrocardiographic findings of a man in his 60s with no history of #cardiovasculardisease who presented to the emergency department with #chestpain of 1 hour’s duration https://ja.ma/337Rbtb
In a randomized, placebo-controlled trial of 4745 patients with recent myocardial infarction, low-dose colchicine (0.5 mg once daily) prevented ischemic cardiovascular events. See the COLCOT trial. #AHA19 https://nej.md/2qOsp3l
Editorial on the COLCOT trial: Inflammation as a Treatment Target after Acute Myocardial Infarction #AHA19 https://nej.md/2CQURUE
In conclusion, the present meta‐analysis indicated that COCs (combined oral contraceptives) containing certain progestins could confer an increased risk of VTE compared with COCs containing levonorgestrel: http://ow.ly/6eUI50wOzPx
#MostCited #VTE
In this week's Perspective Audio Interview, Dr. Kevin De Cock discusses the research and public health benefits of autopsies and other forms of postmortem investigation. https://nej.md/2qWfP1H